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The CRP level is moreclosely correlated with the clinical response to therapy than is the ESR, and is thereforethe preferred marker to monitor treatment success [54]. Concato?J,?Peduzzi?P,?Holford?TR,?Feinstein?AR.?Importance?of?events?per?independent?variable in proportional hazards analysis

Concato?J,?Peduzzi?P,?Holford?TR,?Feinstein?AR.?Importance?of?events?per?independent?variable in proportional hazards analysis. N Engl J Med 2010;362:1022–1029.[16] Waldvogel FA, Medoff G, Swartz MN

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Sample size calculations can be performed using theexpected allele frequency and assuming modest odds (or hazards) ratios (e.g.see Figure 7.3). The research strategiesemployed for quantitative studies are concerned with the means by which observations canbe measured so that results can be expressed numerically. Under normal physiologic con-ditions (homeostasis),the ratesofcell division and cell death are similar. Their muta-tions causing optic atrophy and CMT2A respectively.

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